产品货号：
Z23860
中文名称：
PKC Iota/PRKCI抗体
英文名称：
Anti-PKC Iota/PRKCI Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PKC Iota/PRKCI Antibody |
| 指标别名 | aPKC lambda/iota;DXS1179E;PKC iota;PKCI;PRKC lambda/iota;PRKCI;Protein kinase C iota type;protein kinase C;iota |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | PRKCI |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human PKC iota recombinant protein (Position:D21-Q214).Human PKC iota shares 96% and 97% amino acid (aa) sequence identity with mouse and rat PKC iota,respectively. |
| 实际分子量 | 68KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Protein kinase C iota type,also called PKCI,is an enzyme that in humans is encoded by the PRKCI gene.This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases.This protein kinase is calcium-independent and phospholipid-dependent.It is not activated by phorbolesters or diacylglycerol.This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2,where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway.PRKCI is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis.PRKCI is also a hedgehog target gene that forms a positive feedback loop with GLI and exists at increased levels in basal cell carcinomas. |
| Uniprot ID | P41743 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | protein kinase C,iota |
| 蛋白名全称 | Protein kinase C iota type |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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